Medical Ozone: Definition, Working Mechanisms, Clinical Applications and Management Safety
Medical ozone is understood as high-grade ozone (O₃) that is produced and a predetermined quantity is made for the medical purpose as distinguished from atmospheric ozone,
which is a side product of environmental pollution, while ozone for industrial use is applied in sterilization process. Medical ozone is produced out of 99.99% pure medical oxygen with help of special equipment, thus it is a controlled mixture of ozone and oxygen (usually, 95% oxygen and 5% ozone for the regular use) with guaranteed concentration and quality parameters.
Medical ozone is successfully used in integrative and regenerative medicine globally for more than a century already, hence it has proven to be a good and safe adjunct therapy for several purposes – control of infection, regulation of immunity, reduction of inflammation and improvement of oxygen metabolism in the organism.
Essential Mechanism of Action of Medical Ozone
Mechanisms of therapeutic action of medical ozone are based on its specific oxidation and biochemical properties, acting through three main safe mechanisms on human organisms without resistance to microbes caused by its usage.
One of them is related to disinfection and sterilization. Indeed, medical ozone obtains its ability to penetrate cellular membranes of microorganisms and viruses as well as oxidize and eliminate their internal proteins and nucleic acids. It can be useful in the treatment of skin infections, infections of the wound and fungi infections.Moreover, it encourages microcirculatory dredging, improves the rate of discharge of metabolic toxins from the body, and eases exhaustion and tissue damage because of protracted hypoxia.
On the third place, it has the ability to normalize the immune system and prevent the development of inflammatory processes. In safe therapeutic doses of medical ozone, it triggers the antioxidant protection of the body, intensifies the function of immune cells, forces producing the immune factors like the interferon and interleukin. Additionally, it influences the immune system on both sides since it means boosting the immune system of individuals with weak immune systems and suppressing inflammation in patients suffering from chronic inflammation.
Some of the Main Areas of Use of Medical Ozone
Medical ozone is used widely in different medical conditions and serves as an additional treatment. What follows is the descriptions of some of its successful uses.

1. The area of wound treatment
   The application of medical ozone is the most widely used treatment method forIt is possible to oxidize inflammatory mediators, obtain the release of the adhered tissues and the nerve compression and achieve the instant relieve of chronic pain. Many clinical trials had proved the efficiency and effectiveness of the method as the way of treating joint pain and restore the mobility of patients.
2. Systemic Immune and Metabolic Conditioning
   Medical ozone is used in the standardized systemic administration procedures like MAH to improve the metabolism of oxygen in the blood, prevent the harmful influence of oxidative stress and restore the health conditions of those who suffer from sub-health problems and chronic metabolic conditions. This method is applied in the integrative medicine on a regular basis.
3. Local Anti-infection in Gynecology and Stomatology
   This method is used in gynecology for the treatment of various inflammatory infections and in stomatology for the treatment of oral wounds and problems related to inflammation in the periodontal system.
   Standard Methods of Administration
   Medical ozone procedure should only be performed by# Grammatical errors and word errors are prohibited.

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• Systemic therapy: Major autohemotherapy is the most prevalent method, which processes blood outside of the body and then reintroduces it into the systemic circulation and immune system.

Safety Criteria and Contraindications
Ozone therapy is a safe clinical and helpful therapy, but here it should be borne in mind that it is different from industrial ozone. Introduction of uncontrolled ozone at high concentration can be irritating and toxic, thus, standardized procedure of applying ozone should be rendered.
The Principles of Safe Ozone Use
In clinical practice ozone is applied at low concentration in short duration. In human body ozone would very soon decompose into oxygen without leaving any residue thus resulting not in cumulative poisoning effect. Commercial ozone generators are capable of precise controlling ozone concentration and its delivery in safe doses according to the standard requirements.
Absolute and Relative Contraindications
It is forbidden to apply ozone in treatment of patients with allergy to ozone, severe anemic attack, hyperthyroid crisis or tendency to bleeding. Patients in pregnancy and childhood as well as those who suffer from serious malfunction of organs should consult a doctor before being treated with ozone.
Current Medical Situation and Development
Ozone therapy has been established in European countries, Cuba and some Asian countries. It was successfully integrated into the sphere of standardized integrative medicine. In the USA ozone therapy has not obtained FDA approval yet, however, it is applied legally in several states by authorized doctors.
In recent years, the achievements in the field of regenerative medicine led to the successful implementation of new ozone therapy in clinical practice, giving serious advantages in the form of new studies proving its efficiency as antiinflammatory, antioxidant and immune-modulating therapy.